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Two main strategies have been used to modify the sequences of semaglutide and tirzepatide (red circles) and increase their bioavailability: 1) removal of the DPP-4 cleavage site, replacing alanine with an analogous molecule (α-aminoisobutyric acid (Aib)), but not recognized by the enzyme

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AOD9604 Phase II trials reported the compound was generally well-tolerated at doses tested