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The cadence of updating the list throughout the performance year will enable ACOs to aggregate data throughout the performance year, prepare the majority of their submission data in advance of the submission period, and then use the Quarter 4 list to ensure that all beneficiaries that are eligible for Medicare CQMs are captured in the ACOs' reporting

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In highly specialised settings, a clinician might theoretically consider combining a GH-axis modulator with an incretin-based therapy for a patient with a specific, well-characterised metabolic phenotype — for instance, significant visceral adiposity in the context of HIV-associated lipodystrophy — who has not responded adequately to standard treatments