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Our results suggest that spinal motor neurons of ALS patients have suboptimal protection against ferroptosis and that deficiency of Gpx4 may be a contributing factor to motor neuron degeneration in at least some ALS patients

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Linsitinib also restored the sensitivity of ovarian clear cell carcinoma (OCCC) cells to the chemotherapy drug cisplatin by silencing the IGF-1R/AKT signaling pathway (52)