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Also, the oxidative stress could lead to obesity, and the related comorbidities, by promoting a white adipose tissue deposition (19)

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Hence, it was postulated that the brain drives these psychiatric comorbidities seen in IBS patients, which leads to the conclusion that IBS is a primary brain disorder or somatic symptom disorder whereby the brain is involved in manifesting the gastrointestinal symptoms (Henningsen et al., 2003