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High hyperglycemia causes RTECs to over-activate mTOR and Smad3, inhibit activation of TEFB and transcription, and prevent lysosome neogenesis, which ultimately leads to lysosome exhaustion and the incapacity of autophagosome breakdown by lysosomal enzymes[111]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 763.He, X