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Studies have shown that infection leads to downregulation of expression of HDL synthases including LCAT and HDL transporter proteins such as ABCA1 in the liver and other tissue, which affects the production of HDL and inhibits maturation of HDL following the infection with severe Acute Respiratory Syndrome Coronavirus 2(86), Coronavirus disease 2019 (COVID-19) (87) and Helicobacter pylori (88)