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Spontaneous O 2 − dismutation or catalysis by superoxide dismutase (SOD) action produces hydrogen peroxide (H 2 O 2 ) [22]

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The study was further extended by synthesizing a series of ( E )-2-((substitutedphenyl)diazenyl)phenyl-4-methylbenzenesulfonate ( 12a – b ) and (E)-2-((substituted phenyl)diazenyl)phenol derivatives ( 12c – d ) (Figure 6) and most of the compounds were strongly inhibit the tyrosinase in a dose-dependent manner