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The intrinsic inhibitor, vasohibin, is induced in endothelial cells at later stages of sprouting vessel formation and acts in some fashion as a feedback mechanism to limit excessive angiogenesis (right side of the diagram), e.g., by directly interacting with endothelial cells in sprouting vessels or perhaps by direct interaction with and neutralization of the stimulator(s) which induced vasohibin in endothelial cells ( 13 ).