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The mechanism by which Notch signaling promotes thymocyte glucose metabolism is not entirely clear, but Notch can lead to activation of the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway, which is well established to drive glucose metabolism and aerobic glycolysis in a variety of systems (10)

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5.1.3 PAD4 inhibition PAD4 is mainly expressed in neutrophils and it catalyzes the conversion of histone arginine to citrullination