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One of the main effects of insulin on the adipose tissue and the skeletal muscle is to increase glucose uptake, which is mediated by the increase in vesicular trafficking of the glucose transporter-4 (GLUT4) from intracellular compartments to the plasma membrane, resulting in insulin-stimulated glucose uptake (ISGU) (87)

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The results confirmed that ATF3 siRNA reversed the inhibition of the HSC activation markers Fibronectin, α-SMA, and Collagen I by Art on shown by western blotting (Fig