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Genetic susceptibility, recurrent depressive episodes, low activity levels, poor dietary habits, poor medical care, and side effects of antipsychotics/mood-stabilizers medication have been suggested (McElroy et al., 2002)

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Such methods include methods for detecting hyaluronan-associated disease markers, which include any indication that a subject has a hyaluronan-associated disease, that the subject is likely to respond to treatment by hyaluronan degrading enzyme, and/or that a sample from the subject, such as a tissue, cell or fluid, contains elevated hyaluronan expression