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However, ASS1 is frequently downregulated in fibrotic lung tissues, which promotes fibroblast activation through STAT3 signaling and drives an aggressive, apoptosis-resistant phenotype [87, 88]

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Accordingly, the transferability of our findings should be viewed asymmetrically: the absence of measurable removal in vitro likely argues against clinically meaningful removal in vivo, whereas detectable adsorption in vitro does not necessarily predict clinical relevance