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Although KD consumption for 1 month did not affect Aβ levels in a young amyloid precursor protein (APP)/presenilin-1 (PS-1) knock-in AD mouse model, this diet improved motor performance in AD mice [76]

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Reactions were performed with 50 ⁇ M RHKKAc, a fluorogenic peptide substrate from p53 residues 379-382, 500 ⁇ M NAD+ co-substrate, and recombinant human SIRT-1 (NAD+-dependent) enzyme