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Upon opening of the MPT pores, the outer mitochondrial membrane ruptures, causing the release of many molecules with molecular weights of less than 1.5 kDa from the mitochondrial solutes into the matrix (Karch and Molkentin, 2014)

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GSNO plays a key role in nitric oxide-mediated cellular signaling and can regulate protein function through a process called S-nitrosylation

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