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Table 8: Study design and pharmacokinetic parameters of rat intraduodenal study to assess oral bioavailability of the MEDI7219 (SEQ ID NO:2) peptide formulated with various permeation enhancers

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FIGURE 1 The prevalence of DED, which surged to as high as 61.0% during the COVID-19 pandemic (Ji et al., 2023), underscores the influence of increased exposure to visual display terminals and widespread mask usage during the pandemic, which likely exacerbated the condition by decreasing blink frequency and increasing thermal air currents over the ocular area, thus enhancing tear evaporation rates (Uwimana et al., 2022