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Note that since MitoSOX oxidation, and mitochondrial oxidative stress in general, can arise from ROS generated in the cytoplasm, MitoSOX oxidation is simply a metric of cellular ROS, and not of mitochondrial ROS in particular
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Both of these can increase serotonin, although 5-HTP can be converted to serotonin more quickly ( What’s more, 5-HTP can have other effects, such as decreasing food consumption and body weight ( Doses of 5-HTP may range from 100–900 mg per day ( For those who are most interested in promoting sleep, supplementing with melatonin may be the best choice ( Doses of 0.5–5 mg per day have been used, with 2 mg being the most common dose ( For those who take tryptophan itself, doses of up to 5 grams per day have been reported ( Summary Tryptophan or its products (5-HTP and melatonin) can be taken individually as dietary supplements
