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GEM–STING@Gel, a degradable reactive oxygen species–based hydrogel system, was designed to codeliver gemcitabine and the interferon gene stimulator DMXAA (5,6–dimethylxanthenone – 4 – acetic acid) to tumour sites and regulate the immunosuppressive TME by synergistically activating innate immunity and promoting the infiltration of cytotoxic T lymphocytes (209)
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Cationic polymeric nanoparticles further ensure endosomal escape, allowing siRNA to reach the cytosol and exert gene-silencing effects
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