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Chronic anxiety management benefits from consistent twice-daily dosing, with many patients achieving stable symptom control within the first week of treatment

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In healthy men, an infusion or bolus of kisspeptin (in the form of TAK-448, a synthetic, longer-lasting form of kisspeptin-10) acutely raises testosterone levels, whereas chronic administration lowers testosterone levels substantially (though two subsequent clinical trials assessing TAK-488 were terminated due to lack of efficacy)