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Neurotoxicity is apparently dose-dependent (frequent for 250–350 mg/m 2 , almost certain if dosage exceeds 500–600 mg/m 2 ) [102], although cases of early onset have been described, particularly in patients with neuropathy risk factors [103]

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During treatment, continuous monitoring is essential

Whole proteins (chains of 50 or more amino acids) must be broken down by digestion in order to be absorbed by the body