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Thus, EUK-8 and EUK-134 clearly exhibit antioxidant activity in vivo and can enhance oxidative stress resistance, but without causing lifespan extension

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Exposure to ROS can result in a number of oxidative modifications to DNA including the lesions 8-oxoguanine (8-oxo-dG, 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyG), 4,6-diamino-5-formamidopyrimidine (FapyA), and thymine glycol