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Activation of the Nrf2 pathway enhances the transcription of antioxidant response element (ARE)-dependent genes such as heme oxygenase-1 (HO-1), NAD(P)H quinone dehydrogenase 1 (NQO1), and glutamate–cysteine ligase (GCL), thereby promoting detoxification of ROS and maintenance of redox homeostasis in oocytes ( Figure 3 3 The impact of oxidative stress on the preservation of oocytes and ovarian tissues The most effective method for the cryopreservation of oocytes and ovaries, vitrification, has garnered significant attention due to its rapid cooling capabilities ( 3.1 The impact of oxidative stress on the cryopreservation of oocytes Oxidative stress-induced mitochondrial dysfunction results in oocyte apoptosis
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Nonetheless, MET inhibitors neutralize the irregular expression of PD-L1 caused by MET irregularities, thereby stimulating the cancer-fighting abilities of T and NK cells
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