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Similarly, inhibition of CD38 in aged mice boosted NAD + levels, improving exercise capacity, but in this case, no significant changes in mitochondrial biogenesis-related genes were observed 138

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Certain Bifidobacterium and Lactobacillus species can produce GABA 296,297,298,299,300 , and oral treatment with GABA or bacteria that produce GABA improves metabolic parameters in mice 298,301