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Most of our discussion of the regulation and functions of the mTOR complexes in metabolism has been extracted from studies using cancer models

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The main clinical limitations of STING agonists relate to the risk of excessive systemic inflammation and toxicity (e.g., fever, chills, and CRS (cytokine release syndrome)), particularly with systemic administration, as well as challenges in achieving safe and effective tumor-targeted delivery because intratumoral injections are not feasible for all tumors