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The Bax-interacting factor 1 (Bif-1, also known as Endophilin B1) is also an autophagy-activating protein associated with mitochondria [287, 288]

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For example, researchers have used crisantaspase and glutamine synthetase inhibitor methionine-L-sulfoximine (MSO) to deplete glutamine, which significantly impairs the growth of human hepatocellular carcinoma xenografts (48)