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Doses were not modified in response to these GI AEs, and these events were not the reason for discontinuations

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In addition peroxidase induces oxidative stress and changes in the NAD(+)/NADH redox state, leading to the release of cytochrome C from the mitochondria, dysregulation of the expression of Sirtuins and HIF-1α, and ultimately retinal pigment epithelial (RPE) cell death