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Furthermore, treatment with Fer-1 relieved the inhibition of PDO growth that had been induced by ACTL6A KD, and enabled organoids regained a cystic structure (Fig

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Although the specific mechanisms of RyR2 modification by S-glutathionylation remain to be elucidated, in vitro studies suggest that the S-glutathionylation of RyR2 during preconditioning may have a protective role by increasing systolic Ca 2+ release and decreasing diastolic Ca 2+ leak [116,153]