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It is likely that species differences in antioxidant responses to hypoxia and reoxygenation in animals undergoing prolonged periods of dormancy may reflect different strategies for dealing with the pervasive problems associated with oxidative stress
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Methanol-derived formaldehyde is subsequently oxidized in the cell to formic acid through three additional distinct pathways: cytochrome P450 monooxygenases, cytosolic and mitochondrial aldehyde dehydrogenase (ALDH) isoenzymes, and the primary formaldehyde-oxidizing enzyme gene encoding alcohol dehydrogenase 5 (ADH5), also known as ADH3 or formaldehyde dehydrogenase (FDH) [120]
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