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Cells assigned to the hypoxia treatment were placed in a hypoxia chamber and exposed to a hypoxic gas mixture (94% N 2 , 5% CO 2 , and 1% O 2 ) for indicated time points

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The dysregulation of insulin sensitivity in SF rats may occur at high concentration of H 2 O 2 , because hydrogen peroxide, in the presence of hyperinsulinemia, was reported to have a significant negative effect on insulin signaling and to cause a selective phosphorylation in serine/threonine and loss of IRS1 and 2 proteins which further inhibit insulin response in mammalian skeletal muscle [33, 34]

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