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With cisplatin for initial treatment of locally advanced or metastatic nonsquamous NSCLC: This drug should be administered before cisplatin on Day 1 of each 21-day cycle for up to 6 cycles in the absence of disease progression or unacceptable toxicity

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However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels