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[2] Dose Titration Strategies Starting with doses at the lower end of the therapeutic range (0.5-1.0 mg/kg) and increasing by 0.25-0.5 mg/kg weekly intervals reduces initial side effect burden by approximately 40-50%

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This includes people with pernicious anemia, a condition where the body lacks intrinsic factors, making it impossible to absorb B12 from food

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