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Frontiers | Pathogenic genes implicated in sleep-related hypermotor epilepsy: a research progress update
Solus JF, Arietta BJ, Harris JR, Sexton DP, Steward JQ, McMunn C, et al
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Cluster 3 includes PTGS1, PTGS2 , and ALOX5 involved in prostaglandin metabolism and leukotriene receptor activity, whereas Cluster 4 ( MMP9, MMP2, ITGB8, LOX, TIMP2, and VCAM1 ) and Cluster 5 ( MMP9, MMP2, LOX, TIMP2 ) were found to trigger extracellular matrix organization, elastic fiber formation, and matrix metalloproteinases activity