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Zinkov explains that hormone decline begins as early as our mid-twenties, and symptoms like insomnia, anxiety, mood swings, weight gain, and irregular cycles can start showing up long before periods stop

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Nevertheless, it remains unclear how PDGFα-signaling impacts microgliosis and astrogliosis in these transgenic mice (hPDGFα-GFAP, PDGFαR +/−), since it is known that astrocytes also express PDGFαR and respond to PDGFα (Besnard et al., 1987

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