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The Journal of musculoskeletal medicine, 26(10), 389–396

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glucocorticoid–GR complexes can also activate certain AR target genes leading to enzalutamide resistance Abstract Great strides have been made in the treatment of castration-resistant prostate cancer (CRPC) with the development of new antiandrogens (enzalutamide) and more potent androgen synthesis inhibitors (abiraterone) that have both improved patient outcomes