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Proc Natl Acad Sci USA 92 : 6264–6268 Reaume AG, Elliott JL, Hoffman EK, Kowall NW, Ferrante RJ, Siwek DF, Wilcox HM, Flood DG, Beal MF, Brown RH Jr, Scott RW, Snider WD 1996 Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

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Using liver and fat cells from mice and humans as well as live mouse models, scientists discovered that an enzyme secreted by neutrophils called neutrophil elastase (NE) impaired insulin signaling and boosted resistance