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In the glycolytic pathway, LDH plays a critical role by driving pyruvate’s conversion to lactate coupled with NADH’s oxidation into NAD+, thus maintaining glycolytic flux and supporting cell survival under hypoxic conditions [53]

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Nutlin-3, an inhibitor of murine double minute 2 (MDM2), enhances p53 stability and preserves intracellular GSH levels via a p53-dependent mechanism, allowing cell survival under cystine-deprived conditions (98)