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Endoplasmic reticulum chaperone glucose-regulating protein 78 (GRP78) promoted a CS extract (CSE)-induced inflammatory response and mucus hyperproduction in airway epithelial cells, likely through the upregulation of necroptosis and subsequent activation of the NF-κB and activator protein-1 pathways [91, 92]

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In particular, we highlight the potential of estrogen receptor modulators, hormone replacement therapy (HRT), and alternative treatments in improving mental health and cognitive outcomes in menopausal women