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Similarly, population-based studies evaluating dietary and supplemental zinc intake have shown that excessive zinc consumption, particularly from long-term supplementation, may contribute to altered lipid profiles, impaired glucose regulation, and increased inflammatory burden

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The lack of endothelial BH4 led to coronary blood vessel dysfunction and worsened outcomes for myocardial infarction.[ref] Abdominal aortic aneurysm and BH4 deficiency: Research in mice deficient in BH4 (due to GCH1 mutations) shows that tetrahydrobiopterin and eNOS are important in abdominal aortic aneurysms