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However, as explained by the Alzheimer’s Drug Discovery Foundation in 2024, while urolithin A does have an impressive safety profile, its long-term safety has yet to be established.4 Also, while rare, some people can be allergic to pomegranates, which are rich in the polyphenols that are metabolized into urolithin A.21 This doesn’t necessarily mean that those with pomegranate allergies will have a reaction to urolithin A supplements, but it could be something to keep in mind
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After his first success testing for PKU, Guthrie developed paper cards, called Guthrie Cards, which are thick, absorbent papers each with a metal blade to puncture an infant's heel and places for spotting infant blood
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