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resistance to acid pH, bile tolerance, tolerance to pancreatic fluid, adhesion and invasion capacity in the intestinal epithelial cells ( During the past years, the use of probiotic microorganisms has been applied to modulate the microbiome in a beneficial way and thus fighting against infections threatening human and animal health ( Nevertheless, neither the FDA, more the EFSA have approved the use of probiotics for preventing or treating health issues, despite their classification as safe food supplements ( The Japanese Ministry of Health and Welfare seems to have a different policy