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They are associated with structural (e.g., VSMC proliferation, remodeling of the ECM, increased collagen deposition, collagen crosslinking, and elastin fragmentation) and functional (e.g., VSMC phenotype switching, proinflammatory signaling, endothelial dysfunction, and PVAT dysfunction) vascular wall changes (Fig
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In one aspect of the invention, one or more NNMT inhibitors (such as a cation of Formula I or IA, or otherwise disclosed herein) is contacted with a cell expressing NNMT concurrently with one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that increase intracellular NAD+ levels to provide muscular therapy