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Numerous studies have demonstrated the presence in GBM of a subpopulation of self-renewing and pluripotent GBM stem-like cells (GSCs) responsible for GBM formation, maintenance, invasiveness, and recurrence (Bao et al., 2017) have shown that neural stem cells (NSCs) in the subventricular zone of the human brain might contribute to GBM formation and development, and Lee et al