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To increase the versatility of the linkers for incorporation into cereblon-based PROTACs, it is possible to synthesize or obtain substituted phenyl derivatives (compound 106 ) which, after hydrogenation of the aromatic ring, give compound 107
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Importantly, nuclear-localized FOXO4-positive Leydig cells in elderly testes showed reduced expression of 3β-HSD, a rate-limiting enzyme in testosterone synthesis, implying a connection between nuclear FOXO4 and age-related decline in testosterone production [1]
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