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18 TGF-β functions through its interaction with TGF-β receptors, which phosphorylate SMAD2/3, allowing these proteins to form complexes with SMAD4 that translocate to the nucleus and regulate gene expression

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There are many categories of distinct microbial metabolites including short chain fatty acids (SCFAs), bile acids, neurotransmitters, and other bioactive molecules of microbial origin produced in the gut which influence brain signaling