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Furthermore, increased ACE2 expression in alveolar type II pneumocytes and alveolar macrophages of individuals with severe SARS-CoV-2 disease (ARDS with diffuse alveolar damage) requiring mechanical ventilation (Baker et al., 2021) favors a concomitant increase in oxidative stress in those individuals

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Our study presents the RBC-coated bioreactor as a promising platform for uricase delivery, potentially adaptable for protein or antibody delivery to treat various diseases requiring enzyme replacement therapy