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They include nicotinamide and vitamin B3 derivatives such as nicotinamide riboside (NR) and nicotinamide mono nucleotide (NMN) Footnotes Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication

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They interact with molecular oxygen, generate free radicals to damage adjacent keratinocytes, and stimulate the production of inflammatory mediators in keratinocytes ( 39–41 )