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3.4 Autoimmune Liver Disease Autoimmune liver diseases mainly comprise primary biliary cholangitis (PBC), autoimmune hepatitis (AIH), and primary sclerosing cholangitis (PSC) ( LIGHT , CD40L , interleukin 17 ( IL-17 ), and interferon-γ (IFNγ), while β-Arrestin-1 downregulated H4 acetylation in the promoter regions of HDAC7A , APO2 , and TRAIL in autoreactive T cell line (Table 1) ( via increased T cell proliferation, augmented interferon production, downregulated activities of NF-κB and activating protein-1 (AP-1) ( BCL-xL ) during cholangiocyte senescence, which is important in PSC pathogenesis (Table 1
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This detrimental cycle leads to the accumulation of damaged cellular components, which combine with glutamate-associated excitotoxicity, ultimately culminating in neuronal demise [19] (Fig