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By comparing of efficiency and fidelity of three aaRS-tRNA pairs and corresponding ncAAs (pAzF, pAcF and 4-iodophenylalanine, IodoF) at different incorporation sites, they successfully achieved precise control of HIV-1 replication by supplying or withdrawing AzF as an on/off switch, which enhances vaccine safety and allows for temporal control of HIV-1 viability, mimicking prime-boost vaccination strategies

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Spinal cord or dorsal root ganglion stimulation may cause infection, lead migration, uncomfortable stimulation, hardware failure, loss of benefit, bleeding, and the need for reprogramming, revision, or device removal