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A study conducted on 460 Chinese women with varying bowel movement frequencies employed metagenomic sequencing to analyze gut microbiota and measured serum SCFA levels

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They systematically evaluated the binding affinities of inter- or intra-domain complexes of FOXO3 and TP53, unveiling two strong interactions (i) an intramolecular interaction between the FH and CR3 of FOXO3 and (ii) an intermolecular one between the CR3 of FOXO3 and DBD of TP53