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It is highly expressed at the apical membrane of tubular epithelial cells, and that most of the above-mentioned apical transporters have been reported to directly interact with PDZK1 ( Function of PDZK1 PDZK1 acts as a scaffold protein to regulate the activity of various transport proteins including URAT1 and NPT1 in the proximal tubules ( SLC5A8 ), a high-affinity lactate transport system that interacts with PDZK1, plays an important role in the reabsorption of urate in human kidney ( rs12129861 in PDZK1 is considered a risk allele for gout ( Urate-Lowering Drugs in Hyperuricaemia-Related Diseases At present, there have been many studies on the traditional treatment of hyperuricaemia (Yang et al., 2018)

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Amino Acids 52, 905–914