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Furthermore, noise-induced tinnitus models suggest that compensatory mechanisms, potentially involving nitric oxide (NO) signaling, act to increase neuronal gain in the ventral cochlear nucleus in response to reduced input, a process that appears to involve NMDA receptor facilitation (Hockley et al., 2020)

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Nei modelli preclinici BPC-157 è descritto come eccezionalmente ben tollerato — con un profilo di sicurezza molto elevato ed effetti indesiderati rari e lievi